High-Throughput Screening Identifies Inhibitors for Parvovirus B19 Infection of Human Erythroid Progenitors-Reference-Cited by-同舟云学术

High-Throughput Screening Identifies Inhibitors for Parvovirus B19 Infection of Human Erythroid Progenitors

Published:2022-01-26 Issue:2 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ning Kang¹,Roy Anuradha²,Cheng Fang¹,Xu Peng¹,Kleiboeker Steve³,Escalante Carlos R.⁴,Wang Jingxin⁵,Qiu Jianming¹^ORCID

Affiliation:

1. Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA

2. High Throughput Screening Laboratory, Shankel Structural Biology Center, University of Kansas, Lawrence, Kansas, USA

3. Department of Research and Development, ViraCor Eurofins Laboratories, Lee’s Summit, Missouri, USA

4. Department of Physiology and Biophysics, VCU School of Medicine, Richmond, Virginia, USA

5. Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, USA

Abstract

B19V encodes a large nonstructural protein, NS1. Its N-terminal domain (NS1N) consisting of amino acids 1 to 176 binds to viral DNA and serves as an endonuclease to nick the viral DNA replication origins, which is a pivotal step in rolling-hairpin-dependent B19V DNA replication.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01326-21

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