Discovery of a Series of 2′-α-Fluoro,2′-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus-Reference-Cited by-同舟云学术

Discovery of a Series of 2′-α-Fluoro,2′-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

Published:2019-01-17 Issue:4 Volume:62 Page:1859-1874
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mengshetti Seema¹^ORCID,Zhou Longhu¹,Sari Ozkan¹,De Schutter Coralie¹,Zhang Hongwang¹,Cho Jong Hyun¹,Tao Sijia¹,Bassit Leda C.¹,Verma Kiran¹,Domaoal Robert A.¹,Ehteshami Maryam¹,Jiang Yong¹,Ovadia Reuben¹,Kasthuri Mahesh¹,Ollinger Russell Olivia¹,McBrayer Tamara¹,Whitaker Tony²,Pattassery Judy²,Pascual Maria Luz²,Uher Lothar²,Lin Biing Y.²,Lee Sam²,Amblard Franck¹,Coats Steven J.¹,Schinazi Raymond F.¹^ORCID

Affiliation:

1. Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States

2. Cocrystal Pharma, Inc., Tucker, Georgia 30084, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01300

Reference45 articles.

1. Hepatitis C, Global Health Report; World Health Organization, 2017. http://www.who.int/en/news-room/fact-sheets/detail/hepatitis-c (accessed July 10, 2018).

2. Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection

3. The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection

4. Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights

5. The way forward in HCV treatment — finding the right path

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