Synthesis of 4′-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents-Reference-Cited by-同舟云学术

Synthesis of 4′-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents

Published:2023-02-16 Issue:2 Volume:15 Page:544
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Biteau Nicolas¹,Amichai Sarah¹,Azadi Niloufar¹,De Ramyani¹,Downs-Bowen Jessica¹^ORCID,Lecher Julia¹^ORCID,MacBrayer Tamara¹,Schinazi Raymond¹^ORCID,Amblard Franck¹

Affiliation:

1. Laboratory of Biochemical Pharmacology, Center for ViroScience and Cure, Department of Pediatrics, Emory University School of Medicine, and Children’s Healthcare of Atlanta, Atlanta, GA 30322, USA

Abstract

Over the past decades, both 4′-modified nucleoside and carbocyclic nucleoside analogs have been under the spotlight as several compounds from either family showed anti-HIV, HCV, RSV or SARS-CoV-2 activity. Herein, we designed compounds combining these two features and report the synthesis of a series of novel 4′-substituted carbocyclic uracil derivatives along with their corresponding monophosphate prodrugs. These compounds were successfully prepared in 19 to 22 steps from the commercially available (-)-Vince lactam and were evaluated against a panel of RNA viruses including SARS-CoV-2, influenza A/B viruses and norovirus.

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Link

https://www.mdpi.com/1999-4915/15/2/544/pdf

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