4′-Ethynyl-2′-deoxy-2′-β-fluoro-2-fluoroadenosine: A Highly Potent and Orally Available Clinical Candidate for the Treatment of HIV-1 Infection-Reference-Cited by-同舟云学术

4′-Ethynyl-2′-deoxy-2′-β-fluoro-2-fluoroadenosine: A Highly Potent and Orally Available Clinical Candidate for the Treatment of HIV-1 Infection

Published:2023-08-03 Issue:16 Volume:66 Page:11282-11293
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hou Jiao¹,Peng Youmei²,Liu Bingjie³,Zhang Qianqian¹,Wang Jian-Hua⁴,Yu Wenquan¹^ORCID,Chang Junbiao¹⁴³^ORCID

Affiliation:

1. Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China

2. Henan Key Laboratory for Pharmacology of Liver Diseases, Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China

3. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China

4. Pingyuan Laboratory, State Key Laboratory of Antiviral Drugs, Henan Normal University, Xinxiang 453007, China

Funder

National Key Research and Development Program of China

Central Plains Scholars and Scientists Studio Fund

National Natural Science Foundation of China

Young Backbone Teachers Fund of Henan Province

Henan Province Epidemic Prevention and Control Emergency Research Project

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00761

Reference41 articles.

1. World Health Organization (WHO). Fact Sheets HIV. https://www.who.int/news-room/fact-sheets/detail/hiv-aids (accessed April 26, 2023).

2. The design of drugs for HIV and HCV

3. A Review of HIV-1 Resistance to the Nucleoside and Nucleotide Inhibitors

4. HIV Treatment Adherence, Drug Resistance, Virologic Failure: Evolving Concepts

5. Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

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