Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies
Author:
Publisher
Elsevier BV
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference28 articles.
1. Glucose-lowering effects and safety of DS-8500a, a G protein-coupled receptor 119 agonist, in Japanese patients with type 2 diabetes: results of a randomized, double-blind, placebo-controlled, parallel-group, multicenter, phase II study;Inagaki;BMJ Open Diabetes Res Care,2017
2. Safety and pharmacokinetics of DS-8500a, a novel GPR119 agonist, after multiple oral doses in healthy Japanese males;Kato;Clin Drug Invest,2018
3. DS-8500a, an orally available G protein-coupled receptor 119 agonist, upregulates glucagon-like peptide-1 and enhances glucose-dependent insulin secretion and improves glucose homeostasis in type 2 diabetic rats;Matsumoto;J Pharmacol Exp Therapeut,2018
4. In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions;Makino;Xenobiotica,2019
5. Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560;Bateman;J Mass Spectrom,2006
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