Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [ <sup>14</sup> C]aficamten following single oral dose administration to rats-Reference-Cited by-同舟云学术

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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [ ¹⁴ C]aficamten following single oral dose administration to rats

Published:2024-08-07 Issue: Volume: Page:1-16
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Grillo Mark P.¹,Sukhun Rajaa¹,Bashir Mohammad²,Ashcraft Luke³,Morgan Bradley P.⁴

Affiliation:

1. Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, CA, USA

2. Labcorp Early Development Laboratories Incorporated, Madison, WI, USA

3. Department of Medicinal Chemistry, Cytokinetics, Inc, South San Francisco, CA, USA

4. Research and Non-Clinical Development, Cytokinetics, Inc, South San Francisco, CA, USA

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2024.2381111

Reference11 articles.

1. SPECIES DIFFERENCES IN METABOLISM AND PHARMACOKINETICS OF A SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST IN RATS AND DOGS: FORMATION OF A UNIQUE GLUTATHIONE ADDUCT IN THE RAT

2. Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

3. Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy

4. Plasma-Pooling Methods To Increase Throughput for in Vivo Pharmacokinetic Screening

5. In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor;Xenobiotica;2024-08-09

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