DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats

Author:

Matsumoto Koji,Yoshitomi Tomomi,Ishimoto Yoko,Tanaka Naomi,Takahashi Kanako,Watanabe Akiko,Chiba Katsuyoshi

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference28 articles.

1. Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN-BD11

2. A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure

3. Barnes WG, Nguyen L, Reinhart G, Doebel-Hickok M, Diggs J, Dyck B, Tran J, Harriott ND, Johns M, O-Brien J, et al. (2010) GPR119 demonstrates robust tachyphylaxis following chronic administration of small molecule agonists in Zucker diabetic fatty rats, abstract 679-P, American Diabetes Association 70th Annual Scientific Sessions, Pharmacologic Treatment of Diabetes or its Complications; 2010 25–29 June; Orlando, FL; American Diabetes Association, Arlington County, VA.

4. Effects of an Olive Oil-enriched Diet on Glucagon-like Peptide 1 Release and Intestinal Content, Plasma Insulin Concentration, Glucose Tolerance and Pancreatic Insulin Content in an Animal Model of Type 2 Diabetes

5. A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

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