Safety of nitric oxide added to the ECMO circuit: a pilot study in children-Reference-Cited by-同舟云学术

Safety of nitric oxide added to the ECMO circuit: a pilot study in children

Published:2017-07-21 Issue:1 Volume:33 Page:74-76
ISSN:0267-6591
Container-title:Perfusion
language:en
Short-container-title:Perfusion

Author:

Chiletti Roberto¹,Horton Steve²,Bednarz Andrzej³,Bartlett Robert⁴,Butt Warwick¹

Affiliation:

1. Department of Intensive Care, Royal Children’s Hospital, Melbourne, Australia

2. Perfusion Department, Royal Children’s Hospital, Melbourne, Australia

3. Department of Biomedical Engineering, Royal Children’s Hospital, Melbourne, Australia

4. Department of Surgery, University of Michigan, Ann Arbor, USA

Abstract

We describe our experience of 30 consecutive children supported with ECMO and receiving 20 ppm of nitric oxide in the oxygenator of the ECMO circuit. Administration of nitric oxide into the ECMO circuit is safe and could potentially mitigate ischaemia reperfusion injury and end-organ dysfunction of children requiring mechanical support.

Publisher

SAGE Publications

Subject

Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Safety Research,Radiology, Nuclear Medicine and imaging,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0267659117720495

Reference5 articles.

1. Effect of varying nitric oxide release to prevent platelet consumption and preserve platelet function in an in vivo model of extracorporeal circulation

2. Beneficial Effects of Nitric Oxide on Outcomes after Cardiac Arrest and Cardiopulmonary Resuscitation in Hypothermia-treated Mice

3. Molecular Basis of Cardioprotection

4. Nitric oxide administration during paediatric cardiopulmonary bypass: a randomised controlled trial

5. Nitric oxide delivery during cardiopulmonary bypass reduces postoperative morbidity in children—a randomized trial

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