1. From the Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital Sant'Orsola-Malpighi, University of Bologna, Bologna, Italy (GR, PF, AL, NP, and ER); the Institute of Gerontology and Geriatrics, Perugia University Hospital, Perugia, Italy (FM, RC, and PM); and the Department of Medicine, McMaster University, Hamilton, ON, Canada (CP)