Abstract
AbstractThis study examined the associations between vitamin E, oxidative stress markers, total homocysteine levels, and physical activity or cognitive capacity in older adults. One hundred and six older adults (62 men, 44 women) within the age range of 56–81 years participated. The Global Physical Activity Questionnaire and the Loewenstein Occupational Therapy Cognitive Assessment were used to assess physical activity and cognitive function, respectively. Vitamin E (e.g., α-tocopherol and γ-tocopherol), oxidative stress markers (e.g., total antioxidant capacity and nitric oxide), and total homocysteine were estimated. There were significant associations between physical activity (high versus moderate versus poor) and all biomarkers (all p = 0.000, and p = 0.010 for γ-tocopherol). While total homocysteine and total antioxidant capacity were significantly associated with cognitive capacity (p = 0.000), vitamin E levels (e.g., α-tocopherol and γ-tocopherol) and nitric oxide (p = 0.354, 0.103 and 0.060, respectively) were not related to cognitive capacity in older adults. This study concludes that physical activity was associated with Vitamin E, oxidative stress markers, total homocysteine, and cognitive capacity in older adults. Although cognitive capacity was associated with total homocysteine and total antioxidant capacity, it was unrelated to vitamin E levels and nitric oxide in older adults.
Publisher
Springer Science and Business Media LLC
Reference86 articles.
1. Cherbuin, N., Kumar, R., Sachdev, P. & Anstey, K. J. Dietary mineral intake and risk of mild cognitive impairment: the PATH through life project. Front. Aging Neurosci. 6, 4 (2014).
2. O’Shea, A., Cohen, R., Porges, E. C., Nissim, N. R. & Woods, A. J. Cognitive aging and the hippocampus in older adults. Front. Aging Neurosci. 8, 298 (2016).
3. WHO. Global Action Plan on the Public Health Response to Dementia (WHO, Geneva, 2017).
4. Ferry, M. & Roussel, A.-M. Micronutrient status and cognitive decline in ageing. Eur. Geriatr. Med. 2, 15–21 (2011).
5. Morley, J. E. et al. Brain health: the importance of recognizing cognitive impairment: an IAGG consensus conference. J. Am. Med. Dir. Assoc. 16, 731–739 (2015).
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献