Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old
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Published:2022-12-23
Issue:1
Volume:15
Page:61
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ISSN:2072-6643
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Container-title:Nutrients
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language:en
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Short-container-title:Nutrients
Author:
Melo van Lent DeboraORCID, Egert Sarah, Wolfsgruber Steffen, Kleineidam Luca, Weinhold Leonie, Wagner-Thelen Holger, Stoffel-Wagner Birgit, Bickel Horst, Wiese Birgitt, Weyerer Siegfried, Pentzek Michael, Jessen Frank, Schmid Matthias, Maier Wolfgang, Scherer Martin, Riedel-Heller Steffi G., Ramirez AlfredoORCID, Wagner MichaelORCID
Abstract
Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies.
Funder
German Federal Ministry of Education and Research, BMBF
Subject
Food Science,Nutrition and Dietetics
Reference71 articles.
1. Alzheimer’s disease;Blennow;Lancet,2006 2. Conceptual evolution in Alzheimer’s disease: Implications for understanding the clinical phenotype of progressive neurodegenerative disease;Jicha;J. Alzheimers Dis.,2010 3. Marcos-Perez, D., Sanchez-Flores, M., Proietti, S., Bonassi, S., Costa, S., Teixeira, J.P., Fernandez-Tajes, J., Pasaro, E., Valdiglesias, V., and Laffon, B. (2020). Low Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review and Meta-Analysis. Nutrients, 12. 4. Micronutrient malnutrition across the life course, sarcopenia and frailty;Welch;Proc. Nutr. Soc.,2021 5. Grimm, M.O., Mett, J., and Hartmann, T. (2016). The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimers Disease. Int. J. Mol. Sci., 17.
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