Endocarditis Caused by Nontypeable Streptococcus pneumoniae

Author:

Henriet Stefanie S V1,Langereis Jeroen D2,Lo Stephanie W3,Bentley Stephen3,Mesman Rob J4,Fejzic Zina5,van Niftrik Laura4,van Sorge Nina M6,Wertheim Heiman F L7,de Jonge Marien I2,Cremers Amelieke J H7

Affiliation:

1. Department of Pediatric Infectious Diseases and Immunology, Amalia Children’s Hospital, Radboudumc Center for Infectious Diseases, Radboud University Medical Center , Nijmegen , The Netherlands

2. Laboratory of Medical Immunology, Radboudumc Center for Infectious Diseases, Radboud University Medical Center , Nijmegen , The Netherlands

3. Parasites and Microbes, Wellcome Sanger Institute , Hinxton , United Kingdom

4. Department of Microbiology, Institute for Water and Wetland Research, Faculty of Science, Radboud University , Nijmegen , The Netherlands

5. Department of Pediatric Cardiology, Amalia Children’s Hospital, Radboud University Medical Center , Nijmegen , The Netherlands

6. Department of Medical Microbiology and Infection Prevention and Netherlands Reference Laboratory for Bacterial Meningitis, Amsterdam University Medical Center, University of Amsterdam , Amsterdam , The Netherlands

7. Department of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboud University Medical Center , Nijmegen , The Netherlands

Abstract

Abstract The Streptococcus pneumoniae capsule is regarded as indispensable in bacteremia. We report an infant with a ventricular septal defect and infective endocarditis caused by nontypeable S. pneumoniae. In-depth investigation confirmed a deficient capsule yet favored pneumococcal fitness for causing infective endocarditis, rather than a host immune disorder, as the cause of infective endocarditis in this case.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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