Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics-Reference-Cited by-同舟云学术

Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics

Published:2019-10-20 Issue:1 Volume:71 Page:201-204
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Vannice Kirsten S¹²,Ricaldi Jessica³,Nanduri Srinivas³,Fang Ferric C⁴,Lynch John B⁴,Bryson-Cahn Chloe⁴,Wright Theodore⁴,Duchin Jeff²,Kay Meagan²,Chochua Sopio³,Van Beneden Chris A³,Beall Bernard³

Affiliation:

1. Epidemiology Workforce Branch, Division of Scientific Education and Professional Development, Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Communicable Disease Epidemiology and Immunization, Prevention Division, Public Health–Seattle & King County, Seattle, Washington, USA

3. Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

4. Harborview Medical Center, Seattle, Washington, USA

Abstract

Abstract Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciz1000/31797703/ciz1000.pdf

Reference12 articles.

1. The global burden of group A streptococcal diseases;Carapetis;Lancet Infect Dis,2005

2. Why do we fail with penicillin in the treatment of group A Streptococcus infections?;Sela;Ann Med,1999

3. Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of beta-lactam antibiotics;Grebe;Antimicrob Agents Chemother,1996

4. Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics;Dahesh;Antimicrob Agents Chemother,2008

5. Short-read whole genome sequencing for determination of antimicrobial resistance mechanisms and capsular serotypes of current invasive Streptococcus agalactiae recovered in the USA;Metcalf;Clin Microbiol Infect,2017

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