Point Mutation in the Group B Streptococcal pbp2x Gene Conferring Decreased Susceptibility to β-Lactam Antibiotics-Reference-Cited by-同舟云学术

Point Mutation in the Group B Streptococcal pbp2x Gene Conferring Decreased Susceptibility to β-Lactam Antibiotics

Published:2008-08 Issue:8 Volume:52 Page:2915-2918
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dahesh Samira¹,Hensler Mary E.¹,Van Sorge Nina M.¹,Gertz Robert E.²,Schrag Stephanie²,Nizet Victor¹³,Beall Bernard W.²

Affiliation:

1. Division of Pharmacology and Drug Discovery, Department of Pediatrics

2. Respiratory Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California

Abstract

ABSTRACT Beta-lactam antibiotics (BLAs) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00461-08

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