Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3

Author:

Weber Alexander N R12ORCID,Tapia-Abellán Ana12,Liu Xiao1,Dickhöfer Sabine1,Aróstegui Juan I34ORCID,Pelegrín Pablo56,Welzel Tatjana78ORCID,Kuemmerle-Deschner Jasmin B7

Affiliation:

1. Interfaculty Institute of Cell Biology, Department of Immunology, University of Tübingen , Tübingen, Germany

2. Clusters of Excellence EXC 2180 “Image-Guided and Functionally Instructed Tumor Therapies” and EXC 2124 “Controlling Microbes to Fight Infection”, University of Tübingen , Germany

3. Department of Immunology, Hospital Clinic , Barcelona, Spain

4. Department of Immunology, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi I Sunyer , Barcelona, Spain

5. Department of Biochemistry, Molecular Biology and Immunology, Instituto Murciano de Investigación Biosanitaria Arrixaca, Universidad de Murcia , Murcia, Spain

6. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia , Murcia, Spain

7. Pediatric Rheumatology and Autoinflammation Reference Center, Department of Pediatrics I, University Hospital Tübingen , Tübingen, Germany

8. Department of Pediatric Pharmacology and Pharmacometrics, University Children’s Hospital Basel, University of Basel , Basel, Switzerland

Funder

Deutsche Forschungsgemeinschaft

German Research Foundation

FEDER

Ministerio de Ciencia, Innovación y Universidades–Agencia Estatal de Investigación

European Research Council

Medical Faculty of the Eberhard Karls University Tübingen

University of Tübingen

University Hospital Tübingen

European Reference Network

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Rheumatology

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