Targeting the NLRP3 inflammasome in inflammatory diseases

Author:

Mangan Matthew S. J.,Olhava Edward J.,Roush William R.,Seidel H. Martin,Glick Gary D.,Latz Eicke

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Reference183 articles.

1. Netea, M. G. et al. Trained immunity: a program of innate immune memory in health and disease. Science 352, 1098–1098 (2016).

2. Cooper, M. D. & Alder, M. N. The evolution of adaptive immune systems. Cell 124, 815–822 (2006).

3. GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388, 1459–1544 (2016). This study highlights the rise of non-communicable, lifestyle-based diseases on a global scale.

4. Próchnicki, T., Mangan, M. S. & Latz, E. Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation. F1000Res. 5, 1469 (2016).

5. Próchnicki, T. & Latz, E. Inflammasomes on the crossroads of innate immune recognition and metabolic control. Cell. Metab. 26, 71–93 (2017).

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