Cracking the NLRP3 code: Pioneering precision medicine for inflammation-Reference-Cited by-同舟云学术

Cracking the NLRP3 code: Pioneering precision medicine for inflammation

Published:2024-03-27 Issue:5 Volume:221 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Weber Alexander N.R.¹²^ORCID,Tortola Maria Mateo¹^ORCID,Kuemmerle-Deschner Jasmin B.³

Affiliation:

1. Institute of Immunology, University of Tübingen 1 Department of Innate Immunity, , Tübingen, Germany

2. Clusters of Excellence EXC 2180 “iFIT—Image-Guided and Functionally Instructed Tumor Therapies” and EXC 2124 “CMFI—Controlling Microbes to Fight Infection,” University of Tübingen 2 , Tübingen, Germany

3. Pediatric Rheumatology and Autoinflammation Reference Center Tübingen, University Hospital Tübingen 3 Department of Pediatrics I, , Tübingen, Germany

Abstract

Precisely diagnosing and effectively treating cryopyrin-associated periodic syndrome (CAPS), an inflammatory condition linked to gain-of-function NLRP3 inflammasome mutations, poses challenges. A novel classification approach may help inform therapeutic decisions and offer valuable insights into broader inflammatory conditions (Cosson et al. J. Exp. Med. 2024. https://doi.org/10.1084/jem.20231200).

Funder

Deutsche Forschungsgemeinschaft

Medical Faculty of the Eberhard Karls University Tübingen

European Reference Network

University of Tübingen

Publisher

Rockefeller University Press

Link

https://rupress.org/jem/article-pdf/doi/10.1084/jem.20240221/1926679/jem_20240221.pdf

Reference19 articles.

1. NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation

2. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

3. The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson’s disease models

4. The NLRP3 inhibitor MCC950 inhibits IL-1β production in PBMC from 19 patients with Cryopyrin-Associated Periodic Syndrome and in 2 patients with Schnitzler’s Syndrome

5. Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation

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1. A rare case of uncharacterized autoinflammatory disease: Patient carrying variations in NLRP3 and TNFRSF1A genes;American Journal of Medical Genetics Part A;2024-05-20