Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of siRNA Duplexes-Reference-Cited by-同舟云学术

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Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of siRNA Duplexes

Published:2019-08 Issue:4 Volume:29 Page:187-194
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Malek-Adamian Elise¹,Fakhoury Johans¹,Arnold Amy E.²,Martínez-Montero Saúl¹,Shoichet Molly S.²³⁴,Damha Masad J.¹

Affiliation:

1. Department of Chemistry, McGill University, Montreal, Canada.

2. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Canada.

3. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.

4. Department of Chemistry, University of Toronto, Toronto, Canada.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2019.0792

Reference24 articles.

1. Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

2. Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

3. 4′-C-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing

4. Adjusting the Structure of 2′-Modified Nucleosides and Oligonucleotides via C4′-α-F or C4′-α-OMe Substitution: Synthesis and Conformational Analysis

5. Conformational properties of branched RNA fragments in aqueous solution

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1. Advances in structural-guided modifications of siRNA;Bioorganic & Medicinal Chemistry;2024-08

2. Atom‐Modified gDNA Enhances Cleavage Activity of TtAgo Enabling Ultra‐Sensitive Nucleic Acid Testing;Advanced Science;2024-05-10

3. 4′-C-Acetamidomethyl-2′-O-methoxyethyl Nucleic Acid Modifications Improve Thermal Stability, Nuclease Resistance, Potency, and hAgo2 Binding of Small Interfering RNAs;The Journal of Organic Chemistry;2024-02-23

4. 4′-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics;Chemical Society Reviews;2023

5. Advances in siRNA therapeutics and synergistic effect on siRNA activity using emerging dual ribose modifications;RNA Biology;2022-03-30

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