4′-C-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing-Reference-Cited by-同舟云学术

4′-C-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing

Published:2017-10-06 Issue:41 Volume:139 Page:14542-14555
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Malek-Adamian Elise¹,Guenther Dale C.²,Matsuda Shigeo²,Martínez-Montero Saúl¹,Zlatev Ivan²,Harp Joel³,Burai Patrascu Mihai¹,Foster Donald J.²,Fakhoury Johans¹,Perkins Lydia²,Moitessier Nicolas¹^ORCID,Manoharan Rajar M.²,Taneja Nate²,Bisbe Anna²,Charisse Klaus²,Maier Martin²,Rajeev Kallanthottathil G.²^ORCID,Egli Martin³,Manoharan Muthiah²,Damha Masad J.¹^ORCID

Affiliation:

1. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada

2. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States

3. Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.7b07582

Reference58 articles.

1. Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies

2. siRNA: novel therapeutics from functional genomics

3. Harnessing RNA Interference for Therapy

4. RNAi Therapies: Drugging the Undruggable

5. The chemical evolution of oligonucleotide therapies of clinical utility

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