In Vitro Fungicidal Activities of Echinocandins against Candida metapsilosis , C. orthopsilosis , and C. parapsilosis Evaluated by Time-Kill Studies-Reference-Cited by-同舟云学术

In Vitro Fungicidal Activities of Echinocandins against Candida metapsilosis , C. orthopsilosis , and C. parapsilosis Evaluated by Time-Kill Studies

Published:2010-05 Issue:5 Volume:54 Page:2194-2197
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cantón Emilia¹,Espinel-Ingroff Ana²,Pemán Javier³,del Castillo Lucas⁴

Affiliation:

1. Unidad de Microbiología Experimental, Centro de Investigación, Hospital Universitario La Fe, Valencia 46009, Spain

2. VCU Medical Center, Richmond, Virginia

3. Servicio de Microbiologia, Hospital Universitario La Fe, Valencia 46009, Spain

4. Departamento de Microbiología y Ecología, Facultad de Farmacia, Universidad de Valencia, Valencia, Spain

Abstract

ABSTRACT Anidulafungin, micafungin, and caspofungin in vitro activities against Candida metapsilosis , C. orthopsilosis , and C. parapsilosis were evaluated by MICs and time-kill methods. All echinocandins showed lower MICs (mean MICs, 0.05 to 0.71 mg/liter) and the highest killing rates (−0.06 to −0.05 CFU/ml/h) for C. metapsilosis and C. orthopsilosis rather than for C. parapsilosis (mean MICs, 0.59 to 1.68 mg/liter). Micafungin and anidulafungin killing rates were greater than those determined for caspofungin. None of the echinocandins had fungicidal activity against C. parapsilosis .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01538-09

Reference20 articles.

1. Patterns of Amphotericin B Killing Kinetics against Seven Candida Species

2. Killing Kinetics of Caspofungin, Micafungin, and Amphotericin B against Candida guilliermondii

3. In Vitro Activities of Echinocandins against Candida krusei Determined by Three Methods: MIC and Minimal Fungicidal Concentration Measurements and Time-Kill Studies

4. Characterizing the Effects of Caspofungin on Candida albicans , Candida parapsilosis , and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments

5. Reference method for broth dilution antifungal susceptibility testing of yeasts. 2008

Cited by 56 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. In Vitro Susceptibility Tests in the Context of Antifungal Resistance: Beyond Minimum Inhibitory Concentration in Candida spp.;Journal of Fungi;2023-12-12

2. In Vitro Activity of Fenticonazole against Candida and Bacterial Vaginitis Isolates Determined by Mono- or Dual-Species Testing Assays;Antimicrobial Agents and Chemotherapy;2019-07

3. Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris;Journal of Antimicrobial Chemotherapy;2019-05-12

4. Candida parapsilosis: from Genes to the Bedside;Clinical Microbiology Reviews;2019-03-20

5. Killing kinetics of anidulafungin, caspofungin and micafungin against Candida parapsilosis species complex: Evaluation of the fungicidal activity;Revista Iberoamericana de Micología;2019-01