Killing Kinetics of Caspofungin, Micafungin, and Amphotericin B against Candida guilliermondii-Reference-Cited by-同舟云学术

Killing Kinetics of Caspofungin, Micafungin, and Amphotericin B against Candida guilliermondii

Published:2006-08 Issue:8 Volume:50 Page:2829-2832
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cantón Emilia¹,Pemán Javier²,Sastre Macrina¹,Romero Mónica¹,Espinel-Ingroff Ana³

Affiliation:

1. Unidad de Microbiología Experimental-Centro de Investigación

2. Servicio de Microbiología, Hospital Universitario La Fe, 46009 Valencia, Spain

3. Division of Infectious Disease, VCU Medical Center, Richmond, Virginia 23298-0049

Abstract

ABSTRACT Amphotericin B (AMB), micafungin, and caspofungin MICs, minimal fungicidal concentrations, and time-killing curves were determined in the presence and absence of 10% inactivated serum. AMB was the only agent with consistent killing activity (time required to achieve 99.9% of growth reduction was 2.1 to 3.2 h). The presence of serum enhanced caspofungin activity but lowered those of micafungin and AMB.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00524-06

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