Characterizing the Effects of Caspofungin on Candida albicans , Candida parapsilosis , and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments-Reference-Cited by-同舟云学术

Characterizing the Effects of Caspofungin on Candida albicans , Candida parapsilosis , and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments

Published:2006-07 Issue:7 Volume:50 Page:2569-2572
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Clancy Cornelius J.¹²,Huang Hong²,Cheng Shaoji²,Derendorf Hartmut³,Nguyen M. Hong¹²⁴

Affiliation:

1. North Florida/South Georgia VA Medical Center

2. Departments of Medicine

3. Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, Florida 32610

4. Molecular Genetics and Microbiology, University of Florida College of Medicine

Abstract

ABSTRACT We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans , C. parapsilosis , and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00291-06

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