Functional Characterization of a <i>Bacillus</i> -Derived Novel Broad-Spectrum Antifungal Lipopeptide Variant against Candida tropicalis and Candida auris and Unravelling Its Mode of Action-Reference-Cited by-同舟云学术

Functional Characterization of a Bacillus -Derived Novel Broad-Spectrum Antifungal Lipopeptide Variant against Candida tropicalis and Candida auris and Unravelling Its Mode of Action

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ramesh Swetha¹,Madduri Madhuri¹,Rudramurthy Shivaprakash M.²^ORCID,Roy Utpal¹^ORCID

Affiliation:

1. Department of Biological Sciences, BITS Pilani K.K. Birla Goa Campus, Goa, India

2. Department of Medical Microbiology, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India

Abstract

C. tropicalis is a major concern for candidiasis in India and C. auris has emerged as a resistant yeast causing difficult-to-treat infections. Currently, amphotericin B (AMB) and 5-flucytosine (5-FC) are the main therapeutics for systemic fungal infections; however, the nephrotoxicity of AMB and resistance to 5-FC is a serious concern.

Funder

Indian Council of Medical Research (ICMR)-SRF

DBT/Department of Biotechnology

DST | Science and Engineering Research Board

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01583-22

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