In Vitro Activity of Fenticonazole against Candida and Bacterial Vaginitis Isolates Determined by Mono- or Dual-Species Testing Assays-Reference-Cited by-同舟云学术

In Vitro Activity of Fenticonazole against Candida and Bacterial Vaginitis Isolates Determined by Mono- or Dual-Species Testing Assays

Published:2019-07 Issue:7 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sanguinetti Maurizio¹²^ORCID,Cantón Emilia³,Torelli Riccardo¹,Tumietto Fabio⁴,Espinel-Ingroff Ana⁵,Posteraro Brunella⁶⁷

Affiliation:

1. Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

2. Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy

3. Unidad de Microbiología Experimental, Grupo Multidisciplinar de Infeción Grave, Instituto de Investigación Sanitaria, Hospital La Fe, Valencia, Spain

4. Unità di Malattie Infettive, Dipartimento di Scienze Mediche e Chirurgiche, Ospedale S. Orsola-Malpighi, Università di Bologna, Bologna, Italy

5. VCU Medical Center, Richmond, Virginia, USA

6. Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

7. Istituto di Patologia Medica e Semeiotica Medica, Università Cattolica del Sacro Cuore, Rome, Italy

Abstract

We determined the in vitro activity of fenticonazole against 318 vaginitis isolates of Candida and bacterial species and selected 28 isolates for time-kill studies. At concentrations equal to 4× MIC, fenticonazole reached the 99.9% killing endpoint by ∼10 h for Staphylococcus aureus , Streptococcus agalactiae , and Escherichia coli and by ∼17 h for Candida albicans and Candida parapsilosis ; and at concentrations equal to 8× MIC, by ∼19 and ∼20 h for Candida glabrata and Candida tropicalis , respectively.

Funder

Recordati

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02693-18

Reference25 articles.

1. Vulvovaginal candidosis

2. Candidavulvovaginitis: A store with a buttery and a show window

3. Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors