Intra- and Interspecies Spread of a Novel Conjugative Multidrug Resistance IncC Plasmid Coharboring bla OXA-181 and armA in a Cystic Fibrosis Patient-Reference-Cited by-同舟云学术

Intra- and Interspecies Spread of a Novel Conjugative Multidrug Resistance IncC Plasmid Coharboring bla _OXA-181 and armA in a Cystic Fibrosis Patient

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Fernandez Javier E.¹²,Seth-Smith Helena M. B.³⁴^ORCID,Nordmann Patrice⁵^ORCID,Egli Adrian³⁴,Endimiani Andrea⁶^ORCID,Perreten Vincent¹^ORCID

Affiliation:

1. Division of Molecular bacterial Epidemiology and Infectious Diseases, Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

2. Graduate School of Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

3. Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland

4. Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland

5. Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Fribourg, Switzerland

6. Institute for Infectious Diseases (IFIK), University of Bern, Bern, Switzerland

Abstract

Colocalization of carbapenemases and aminoglycoside resistance 16S rRNA methylases on a multidrug resistance conjugative plasmid poses a serious threat to public health. Here, we describe the novel IncC plasmid pJEF1-OXA-181 cocarrying bla OXA-181 and armA as well as several other antimicrobial resistance genes (ARGs) in different Enterobacterales isolates of the sputum and gut microbiota of a cystic fibrosis patient.

Funder

Bundesamt für Lebensmittelsicherheit und Veterinärwesen

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03121-22

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5. Complete Nucleotide Sequence of Klebsiella pneumoniae Multidrug Resistance Plasmid pKP048, Carrying bla KPC-2 , bla DHA-1 , qnrB4 , and armA

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