Complete Nucleotide Sequence of Klebsiella pneumoniae Multidrug Resistance Plasmid pKP048, Carrying bla KPC-2 , bla DHA-1 , qnrB4 , and armA-Reference-Cited by-同舟云学术

Complete Nucleotide Sequence of Klebsiella pneumoniae Multidrug Resistance Plasmid pKP048, Carrying bla KPC-2 , bla DHA-1 , qnrB4 , and armA

Published:2010-09 Issue:9 Volume:54 Page:3967-3969
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jiang Yan¹,Yu Dongliang²³,Wei Zeqing⁴,Shen Ping⁴,Zhou Zhihui¹,Yu Yunsong¹

Affiliation:

1. Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016

2. James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou, Zhejiang 310008

3. Center of Biomedical and Health, Hangzhou Normal University, Hangzhou, Zhejiang 310012

4. State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China

Abstract

ABSTRACT The Klebsiella pneumoniae multidrug resistance plasmid pKP048 was completely sequenced. This plasmid carries several important resistance determinants, such as bla KPC-2 , bla DHA-1 , qnrB4 , and armA , which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively. Analysis of the finished 151,188-bp sequence data revealed 163 putative genes, 108 of which were assigned functions such as replication, stable inheritance, antibiotic resistance, a mobile element, conjugal transfer, and a restriction-modification system, showing the strong phylogenetic mosaicism and plasticity of the plasmid.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00137-10

Reference17 articles.

1. Macrolide Efflux in Streptococcus pneumoniae Is Mediated by a Dual Efflux Pump ( mel and mef ) and Is Erythromycin Inducible

2. Plasmid-Mediated 16S rRNA Methylases among Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae Isolates

3. Dynamics of the IncW genetic backbone imply general trends in conjugative plasmid evolution

4. Gaillot, O., C. Clement, M. Simonet, and A. Philippon. 1997. Novel transferable beta-lactam resistance with cephalosporinase characteristics in Salmonella enteritidis. J. Antimicrob. Chemother.39:85-87.

5. Galani, I., F. Kontopidou, M. Souli, P. D. Rekatsina, E. Koratzanis, J. Deliolanis, and H. Giamarellou. 2008. Colistin susceptibility testing by Etest and disk diffusion methods. Int. J. Antimicrob. Agents31:434-439.

Cited by 109 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification of a Novel KPC Variant, KPC-204, Conferring Resistance to Both Carbapenems and Ceftazidime–Avibactam in an ST11 Klebsiella pneumoniae Strain;Microorganisms;2024-06-13

2. Coexistence of a novel chromosomal integrative and mobilizable element Tn7548 with two blaKPC-2-carrying plasmids in a multidrug-resistant Aeromonas hydrophila strain K522 from China;Journal of Global Antimicrobial Resistance;2024-06

3. Molecular Analysis of Carbapenem and Aminoglycoside Resistance Genes in Carbapenem-Resistant Pseudomonas aeruginosa Clinical Strains: A Challenge for Tertiary Care Hospitals;Antibiotics;2024-02-16

4. Molecular epidemiology of carbapenem-resistant Escherichia coli in a tertiary hospital located in the Dabie Mountains region, China;2024-02-12

5. Carbapenem-resistant Klebsiella pneumoniae : the role of plasmids in emergence, dissemination, and evolution of a major clinical challenge;Expert Review of Anti-infective Therapy;2024-01-30