The Global Ascendency of OXA-48-Type Carbapenemases

Author:

Pitout Johann D. D.1234,Peirano Gisele12,Kock Marleen M.45,Strydom Kathy-Anne45,Matsumura Yasufumi6ORCID

Affiliation:

1. Division of Microbiology, Alberta Public Laboratories, Edmonton, Alberta, Canada

2. Department of Pathology & Laboratory Medicine, University of Calgary, Cummings School of Medicine, Calgary, Alberta, Canada

3. Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Cummings School of Medicine, Calgary, Alberta, Canada

4. Department of Medical Microbiology, University of Pretoria, Pretoria, Gauteng, South Africa

5. National Health Laboratory Service, Pretoria, Gauteng, South Africa

6. Kyoto University Graduate School of Medicine, Kyoto, Japan

Abstract

Surveillance studies have shown that OXA-48-like carbapenemases are the most common carbapenemases in Enterobacterales in certain regions of the world and are being introduced on a regular basis into regions of nonendemicity, where they are responsible for nosocomial outbreaks. OXA-48, OXA-181, OXA-232, OXA-204, OXA-162, and OXA-244, in that order, are the most common enzymes identified among the OXA-48-like carbapenemase group.

Funder

Calgary Laboratory Services

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

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