A Negative Regulator of Carotenogenesis in Blakeslea trispora-Reference-Cited by-同舟云学术

A Negative Regulator of Carotenogenesis in Blakeslea trispora

Published:2020-03-02 Issue:6 Volume:86 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Luo Wei¹,Gong Zunyang¹,Li Na¹,Zhao Yuzheng²,Zhang Huili³,Yang Xue⁴,Liu Yuantao⁴,Rao Zhiming¹,Yu Xiaobin¹

Affiliation:

1. The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China

2. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, People’s Republic of China

3. College of Life Sciences, University of Shihezi, Shihezi, People’s Republic of China

4. Hulunbeier Northest Fufeng Biotechnologies Co., Ltd., Zhalantun, People’s Republic of China

Abstract

The zygomycete Blakeslea trispora is an important strain for the production of carotenoids on a large scale. However, the regulation mechanism of carotenoid biosynthesis is still not well understood in this filamentous fungus. In the present study, we sought to investigate how crgA influences the expression of structural genes for carotenoids, carotenoid biosynthesis, and other anabolic phenotypes. This will lead to a better understanding of the global regulation mechanism of carotenoid biosynthesis and facilitate engineering this strain in the future for enhanced production of carotenoids.

Funder

the National Natural Science Foundation of China

the Open Funding Project of the State Key Laboratory of Bioreactor Engineering

the Program of the Key Laboratory of Industrial Biotechnology, Ministry of Education, China

the Project Funded by China Postdoctoral Science Foundation

the Fundamental Research Funds for the Central Universities

the 111 Project

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.02462-19

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