Mutations Associated with Sulfadoxine-Pyrimethamine and Chlorproguanil Resistance in Plasmodium falciparum Isolates from Blantyre, Malawi-Reference-Cited by-同舟云学术

Mutations Associated with Sulfadoxine-Pyrimethamine and Chlorproguanil Resistance in Plasmodium falciparum Isolates from Blantyre, Malawi

Published:2005-09 Issue:9 Volume:49 Page:3919-3921
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alker Alisa P.¹,Mwapasa Victor²,Purfield Anne³,Rogerson Stephen J.⁴,Molyneux Malcolm E.⁵,Kamwendo Deborah D.⁶,Tadesse Eyob⁷,Chaluluka Ebbie⁵,Meshnick Steven R.¹²³

Affiliation:

1. Department of Epidemiology, UNC Chapel Hill School of Public Health, Chapel Hill, North Carolina

2. Department of Community Health, College of Medicine, Blantyre, Malawi

3. Deparment of Microbiology, UNC Chapel Hill School of Medicine, Chapel Hill, North Carolina

4. Department of Medicine, University of Melbourne, Parkville, Victoria 3052, Australia

5. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi

6. Department of Epidemiology, University of Michigan, Ann Arbor, Michigan

7. Department of Obstetrics and Gynecology, College of Medicine, Blantyre, Malawi

Abstract

ABSTRACT We conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.9.3919-3921.2005

Reference17 articles.

1. Rapid Real-Time PCR Genotyping of Mutations Associated with Sulfadoxine-Pyrimethamine Resistance in Plasmodium falciparum

2. Alloueche, A., W. Bailey, S. Barton, J. Bwika, P. Chimpeni, C. O. Falade, F. A. Fehintola, J. Horton, S. Jaffar, T. Kanyok, P. G. Kremsner, J. G. Kublin, T. Lang, M. A. Missinou, C. Mkandala, A. M. Odoula, Z. Premji, L. Robertson, A. Sowunmi, S. A. Ward, and P. A. Winstanley. 2004. Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial. Lancet363:1843-1848.

3. Berens, N., B. Schwoebel, S. Jordan, V. Vanisaveth, R. Phetsouvanh, E. M. Christophel, S. Phompida, and T. Jelinek. 2003. Plasmodium falciparum: correlation of in vivo resistance to chloroquine and antifolates with genetic polymorphisms in isolates from the south of Lao PDR. Trop. Med. Int. Health8:775-782.

4. Biswas, S., A. Escalante, S. Chaiyaroj, P. Angkasekwinai, and A. A. Lal. 2000. Prevalence of point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum isolates from India and Thailand: a molecular epidemiologic study. Trop. Med. Int. Health5:737-743.

5. Bwijo, B., A. Kaneko, M. Takechi, I. L. Zungu, Y. Moriyama, L. K. Lum, T. Tsukahara, T. Mita, N. Takahashi, Y. Bergqvist, A. Bjorkman, and T. Kobayakawa. 2003. High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi. Acta Trop.85:363-373.

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