Clinical Characteristics and Immune Injury Mechanisms in 71 Patients with COVID-19-Reference-Cited by-同舟云学术

Clinical Characteristics and Immune Injury Mechanisms in 71 Patients with COVID-19

Published:2020-08-26 Issue:4 Volume:5 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Wu Yingjie¹,Huang Xiaoxing²,Sun Jiaxing³,Xie Tian³,Lei Yufei³,Muhammad Jamal³,Li Xinran⁴,Zeng Xingruo³,Zhou Fuling⁵,Qin Hong⁶,Shao Liang⁵,Zhang Qiuping³^ORCID

Affiliation:

1. Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China

2. Department of Blood Transfusion, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China

3. Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, People’s Republic of China

4. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

5. Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China

6. Department of Medical Insurance Management, Zhongnan Hospital of Wuhan University, Wuhan, China

Abstract

The dysregulation of CD3 + CD8 + T lymphocytes, CD16 + CD56 + NK cells, C1q as well as IL-6, along with bacterial coinfection, were important causes of exacerbation of the patients’ condition and death.

Funder

MOE | Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00362-20

Reference19 articles.

1. The many faces of the anti-COVID immune response

2. Cytokine release syndrome in severe COVID-19