The many faces of the anti-COVID immune response-Reference-Cited by-同舟云学术

The many faces of the anti-COVID immune response

Published:2020-04-30 Issue:6 Volume:217 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Vardhana Santosha A.¹²³^ORCID,Wolchok Jedd D.³⁴⁵^ORCID

Affiliation:

1. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY

2. Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY

3. Parker Institute for Cancer Immunotherapy, San Francisco, CA

4. Human Oncology Pathogenesis Program, Department of Medicine and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY

5. Weill Cornell Medicine and Graduate School of Biomedical Sciences, New York, NY

Abstract

The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.

Funder

Burroughs Wellcome Fund

Memorial Sloan Kettering Cancer Center

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/doi/10.1084/jem.20200678/1414652/jem_20200678.pdf

Reference100 articles.

1. Successful use of intravenous N-acetylcysteine in dengue haemorrhagic fever with acute liver failure;Abeysekera;Ceylon Med. J,2012

2. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence;Ahmed;J. Exp. Med,1984