Human plasma and liver concentrations of styrene estimated by combining a simple physiologically based pharmacokinetic model with rodent data
Author:
Affiliation:
1. Showa Pharmaceutical University
2. Central Institute for Experimental Animals
3. Shin Nippon Biomedical Laboratories, Ltd.
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/44/8/44_543/_pdf
Reference28 articles.
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2. Boogaard, P.J., de Kloe, K.P., Wong, B.A., Sumner, S.C., Watson, W.P. and van Sittert, N.J. (2000): Quantification of DNA adducts formed in liver, lungs, and isolated lung cells of rats and mice exposed to (14)C-styrene by nose-only inhalation. Toxicol. Sci., 57, 203-216.
3. Csanády, G.A., Kessler, W., Hoffmann, H.D. and Filser, J.G. (2003): A toxicokinetic model for styrene and its metabolite styrene-7,8-oxide in mouse, rat and human with special emphasis on the lung. Toxicol. Lett., 138, 75-102.
4. Emoto, C., Murayama, N., Rostami-Hodjegan, A. and Yamazaki, H. (2009): Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: impact of plasma and microsomal binding. Xenobiotica, 39, 227-235.
5. Fukami, T., Katoh, M., Yamazaki, H., Yokoi, T. and Nakajima, M. (2008): Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene. Chem. Res. Toxicol., 21, 720-725.
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