Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model-Reference-Cited by-同舟云学术

Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model

Published:2021 Issue:9 Volume:46 Page:391-399
ISSN:0388-1350
Container-title:The Journal of Toxicological Sciences
language:en
Short-container-title:J. Toxicol. Sci.

Author:

Yanagi Mayu¹,Kamiya Yusuke¹,Murayama Norie¹,Banju Kaito¹,Shimizu Makiko¹,Yamazaki Hiroshi¹

Affiliation:

1. Showa Pharmaceutical University

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Link

https://www.jstage.jst.go.jp/article/jts/46/9/46_391/_pdf

Reference26 articles.

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3. Hirono, I., Haga, M., Fujii, M., Matsuura, S., Matsubara, N., Nakayama, M., Furuya, T., Hikichi, M., Takanashi, H., Uchida, E., Hosaka, S. and Ueno, I. (1979): Induction of hepatic tumors in rats by senkirkine and symphytine. J. Natl. Cancer Inst., 63, 469-472.

4. Hirono, I., Mori, H., Yamada, K., Hirata, Y. and Haga, M. (1977): Carcinogenic activity of petasitenine, a new pyrrolizidine alkaloid isolated from Petasites japonicus Maxim. J. Natl. Cancer Inst., 58, 1155-1157.

5. Jamei, M., Marciniak, S., Feng, K., Barnett, A., Tucker, G. and Rostami-Hodjegan, A. (2009): The Simcyp population-based ADME simulator. Expert Opin. Drug Metab. Toxicol., 5, 211-223.

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