Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations
Author:
Affiliation:
1. Showa Pharmaceutical University
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/46/8/46_371/_pdf
Reference21 articles.
1. Abraham, K., Wöhrlin, F., Lindtner, O., Heinemeyer, G. and Lampen, A. (2010): Toxicology and risk assessment of coumarin: focus on human data. Mol. Nutr. Food Res., 54, 228-239.
2. Baltazar, M.T., Cable, S., Carmichael, P.L., Cubberley, R., Cull, T., Delagrange, M., Dent, M.P., Hatherell, S., Houghton, J., Kukic, P., Li, H., Lee, M.Y., Malcomber, S., Middleton, A.M., Moxon, T.E., Nathanail, A.V., Nicol, B., Pendlington, R., Reynolds, G., Reynolds, J., White, A. and Westmoreland, C. (2020): A next-generation risk assessment case study for coumarin in cosmetic products. Toxicol. Sci., 176, 236-252.
3. Born, S.L., Caudill, D., Fliter, K.L. and Purdon, M.P. (2002): Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation. Drug Metab. Dispos., 30, 483-487.
4. Born, S.L., Caudill, D., Smith, B.J. and Lehman-McKeeman, L.D. (2000): In vitro kinetics of coumarin 3,4-epoxidation: application to species differences in toxicity and carcinogenicity. Toxicol. Sci., 58, 23-31.
5. Hadidi, H., Irshaid, Y., Vågbø, C.B., Brunsvik, A., Cholerton, S., Zahlsen, K. and Idle, J.R. (1998): Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6. Eur. J. Clin. Pharmacol., 54, 437-441.
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