Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsadogenic risk of fexofenadine-Reference-Cited by-同舟云学术

Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsadogenic risk of fexofenadine

Published:2018 Issue:3 Volume:43 Page:183-192
ISSN:0388-1350
Container-title:The Journal of Toxicological Sciences
language:en
Short-container-title:J. Toxicol. Sci.

Author:

Ando Kentaro¹²,Nakamura Yuji¹,Hagiwara-Nagasawa Mihoko¹,Harada Hiroyuki³,Miyamoto Hiroyoshi³,Inamura Naoki³,Takagi Kan³,Goto Ai²,Chiba Koki²,Lubna Nur Jaharat²,Izumi-Nakaseko Hiroko¹,Naito Atsuhiko T.¹²,Sugiyama Atsushi¹²

Affiliation:

1. Department of Pharmacology, Faculty of Medicine, Toho University

2. Department of Pharmacology, Toho University Graduate School of Medicine

3. Mitsubishi Tanabe Pharma Corporation, Safety Research Laboratories, Sohyaku Innovative Research Division

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Link

https://www.jstage.jst.go.jp/article/jts/43/3/43_183/_pdf

Reference26 articles.

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2. Craig-McFeely, P.M., Freemantle, S.L., Pearce, G.L. and Shakir, S.A. (2000): QT lengthening and life-threatening arrhythmias associated with fexofenadine. Br. J. Gen. Pract., 50, 148.

3. Hove-Madsen, L., Llach, A., Molina, C.E., Prat-Vidal, C., Farré, J., Roura, S. and Cinca, J. (2006): The proarrhythmic antihistaminic drug terfenadine increases spontaneous calcium release in human atrial myocytes. Eur. J. Pharmacol., 553, 215-221.

4. Ishizaka, T., Takahara, A., Iwasaki, H., Mitsumori, Y., Kise, H., Nakamura, Y. and Sugiyama, A. (2010): Cardiovascular effects of azelnidipine in comparison with those of amlodipine assessed in the halothane-anaesthetized dog. Basic Clin. Pharmacol. Toxicol., 106, 135-143.

5. Izumi-Nakaseko, H., Nakamura, Y., Cao, X., Ohara, H., Yamazaki, Y., Ueda, N., Ando, K. and Sugiyama, A. (2014): Effects of selective I_Kr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs. Eur. J. Pharmacol., 740, 263-270.

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