In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys-Reference-Cited by-同舟云学术

In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys

Published:2020-08 Issue:4 Volume:143 Page:272-280
ISSN:1347-8613
Container-title:Journal of Pharmacological Sciences
language:en
Short-container-title:Journal of Pharmacological Sciences

Author:

Goto Ai,Sakamoto Kengo,Hagiwara-Nagasawa Mihoko,Kambayashi Ryuichi,Chiba Koki,Nunoi Yoshio,Izumi-Nakaseko Hiroko,Takei Yoshinori,Matsumoto Akio,Sugiyama Atsushi

Funder

JSPS

Publisher

Elsevier BV

Subject

Pharmacology,Molecular Medicine

Reference20 articles.

1. Effects of moxifloxacin on the proarrhythmic surrogate markers in healthy Filipino subjects: exposure-response modeling using ECG data of thorough QT/QTc study;Matsukura;J Pharmacol Sci,2018

2. Moxifloxacin-induced QT interval prolongation and torsades de pointes: a narrative review;Khan;Expet Opin Drug Saf,2018

3. QT/QTc study conducted in Japanese adult healthy subjects: a novel xanthine oxidase inhibitor topiroxostat was not associated with QT prolongation;Sugiyama;J Clin Pharmacol,2013

4. Clinical experience with moxifloxacin in patients with respiratory tract infections;Faich;Ann Pharmacother,2004

5. Retrospective analysis of the safety profile of oral moxifloxacin in elderly patients enrolled in clinical trials;Andriole;Drug Saf,2005

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1. Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart;Frontiers in Pharmacology;2023-01-19

2. Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile;Toxicological Sciences;2022-08-22

3. Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model;Toxicological Sciences;2021-02-05

4. Identification of Drug-Induced Multichannel Block and Proarrhythmic Risk in Humans Using Continuous T Vector Velocity Effect Profiles Derived From Surface Electrocardiograms;Frontiers in Physiology;2020-09-18