Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs

Author:

Izumi-Nakaseko Hiroko,Nakamura Yuji,Cao Xin,Ohara Hiroshi,Yamazaki Yukiko,Ueda Naoya,Ando Kentaro,Sugiyama Atsushi

Funder

Ministry of Education, Culture, Sports, Science and Technology in Japan

Japan Science and Technology Agency

Toho University Graduate School of Medicine

Toho University Joint Research Fund

Publisher

Elsevier BV

Subject

Pharmacology

Reference36 articles.

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2. Dominant anti-vagal effect of pentobarbital on cardiac responses to intracardiac autonomic nerve stimulation in the dog;Chiba;Jpn. J. Pharmacol.,2001

3. The thorough QT study four years after the implementation of the ICH E14 guidance;Darpo;Br. J. Pharmacol.,2010

4. Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (IKr) channel;Davie;J. Cardiovasc. Electrophysiol.,2004

5. Food and Drug Administration, 2005a. ICH Harmonised Tripartite Guideline, The Non-clinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals S7B. Recommended for adoption at step 4 of the ICH process on 12 May 2005 by the ICH Steering Committee. ICH; 〈http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S7B/Step4/S7B_Guideline.pdf〉 (accessed 18.12.13.).

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