TAZ is important for maintenance of the integrity of podocytes

Author:

Chen Jianchun123ORCID,Wang Xiaoyong2,He Qian2,Harris Raymond C.1234

Affiliation:

1. United States Department of Veterans Affairs, Nashville, Tennessee

2. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

3. Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, Tennessee

4. Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee

Abstract

Podocytes play an important role in maintaining the integrity of the structure and function of the kidney. We observed that mice with selective deletion of transcriptional coactivator with PDZ-binding motif (TAZ) in podocytes developed proteinuria. TAZ is constitutively active and critical for expression of synaptopodin, zonula occludens-1, and zonula occludens-2 in podocytes. The findings of this study implicate TAZ as an important mediator of podocyte structural integrity and provide further insights into the role of Hippo-Yes-associated protein/TAZ in podocyte biology.

Funder

American Diabetes Association Research Foundation

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Veterans Affairs

VUMC | Vanderbilt O'Brien Kidney Center

Publisher

American Physiological Society

Subject

Physiology

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