Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post

Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post–unrelated HCT

Published:2021-01-05 Issue:1 Volume:5 Page:66-70
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Wang Yiwen¹,Zhou Weiyin²³,Wang Junke¹,Karaesmen Ezgi¹^ORCID,Tang Hancong¹,McCarthy Philip L.⁴^ORCID,Pasquini Marcelo C.⁵^ORCID,Wang Youjin²,McReynolds Lisa J.²,Katki Hormuzd A.²,Machiela Mitchell J.²,Yeager Meredith²³,Pooler Loreall⁶,Sheng Xin⁶^ORCID,Haiman Christopher A.⁶,Van Den Berg David⁶,Spellman Stephen R.⁷,Wang Tao⁸⁹,Kuxhausen Michelle⁷,Chanock Stephen J.²,Lee Stephanie J.⁸¹⁰^ORCID,Clay-Gilmour Alyssa I.¹¹,Hahn Theresa E.⁴,Gadalla Shahinaz M.²^ORCID,Sucheston-Campbell Lara E.¹¹²

Affiliation:

1. College of Pharmacy, The Ohio State University, Columbus, OH;

2. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD;

3. Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD;

4. Department of Medicine, Roswell Park Comprehensive Cancer Institute, Buffalo, NY;

5. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI;

6. Department of Preventive Medicine, University of Southern California, Los Angeles, CA;

7. Center for International Blood and Marrow Transplant Research, Minneapolis, MN;

8. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI

9. Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI;

10. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

11. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC; and

12. College of Veterinary Medicine, The Ohio State University, Columbus, OH

Abstract

Key Points Pre-HCT mosaicism is related to increased relapse risk and lower survival after unrelated HCT, independent of cytogenetics at diagnosis. Pre-HCT mosaicism could be a useful clinical tool to guide risk stratification in acute lymphoblastic leukemia patients.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/5/1/66/1796329/advancesadv2020003366.pdf

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