Exome chip analyses identify genes affecting mortality after HLA-matched unrelated-donor blood and marrow transplantation-Reference-Cited by-同舟云学术

Exome chip analyses identify genes affecting mortality after HLA-matched unrelated-donor blood and marrow transplantation

Published:2018-05-31 Issue:22 Volume:131 Page:2490-2499
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhu Qianqian¹^ORCID,Yan Li¹,Liu Qian¹,Zhang Chi²,Wei Lei¹,Hu Qiang¹,Preus Leah³,Clay-Gilmour Alyssa I.⁴,Onel Kenan⁵,Stram Daniel O.⁶,Pooler Loreall⁶,Sheng Xin⁶,Haiman Christopher A.⁶,Zhu Xiaochun⁷,Spellman Stephen R.⁸,Pasquini Marcelo⁷,McCarthy Philip L.⁹,Liu Song¹,Hahn Theresa⁹,Sucheston-Campbell Lara E.³¹⁰

Affiliation:

1. Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY;

2. School of Biological Sciences, University of Nebraska–Lincoln, Lincoln, NE;

3. College of Pharmacy, The Ohio State University, Columbus, OH;

4. Mayo Clinic, Rochester, MN;

5. Department of Pediatric Hematology/Oncology, Cohen Children's Medical Center, Northwell Health, Manhasset, NY;

6. Preventive Medicine, University of Southern California, Los Angeles, CA;

7. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

8. Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, MN;

9. Blood and Marrow Transplant Program, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY; and

10. College of Veterinary Medicine, The Ohio State University, Columbus, OH

Abstract

Key Points We conducted the first exome-wide association study between germ line variant genotype and survival outcomes after unrelated-donor BMT. A number of novel genes were found to significantly affect survival outcomes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/22/2490/1468330/blood817973.pdf

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