Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant

Author:

Karaesmen Ezgi1,Rizvi Abbas A.1,Preus Leah M.1,McCarthy Philip L.2,Pasquini Marcelo C.3,Onel Kenan4,Zhu Xiaochun3,Spellman Stephen5,Haiman Christopher A.6,Stram Daniel O.6,Pooler Loreall6,Sheng Xin6,Zhu Qianqian7,Yan Li7,Liu Qian7,Hu Qiang7,Webb Amy8,Brock Guy8,Clay-Gilmour Alyssa I.9,Battaglia Sebastiano10,Tritchler David11,Liu Song7,Hahn Theresa2,Sucheston-Campbell Lara E.112

Affiliation:

1. College of Pharmacy, The Ohio State University, Columbus, OH;

2. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY;

3. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

4. Department of Pediatrics, Northwell Health, Manhasset, NY;

5. Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN;

6. Preventive Medicine, University of Southern California, Los Angeles, CA;

7. Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY;

8. Biomedical Informatics, The Ohio State University, Columbus, OH;

9. Cancer Genetic Epidemiology, Division of Epidemiology, The Mayo Clinic, Rochester, MN;

10. Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY;

11. Biostatistics, State University of New York at Buffalo, Buffalo, NY; and

12. College of Veterinary Medicine, The Ohio State University, Columbus, OH

Abstract

Key Points Candidate SNP associations with survival outcomes after URD transplant are most likely false-positive findings. Over 85% of candidate SNPs are not linked to a biochemical function; of those that are, about half are not linked to the candidate gene.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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