Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells-Reference-Cited by-同舟云学术

Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells

Published:2013-09-26 Issue:13 Volume:122 Page:2213-2223
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Peters Jorieke H.¹,Koenen Hans J. P. M.¹,Fasse Esther¹,Tijssen Henk J.¹,IJzermans Jan N. M.²,Groenen Patricia J. T. A.³,Schaap Nicolaas P. M.⁴,Kwekkeboom Jaap⁵,Joosten Irma¹

Affiliation:

1. Department of Laboratory Medicine–Medical Immunology, Radboud University Medical Centre, Nijmegen, The Netherlands;

2. Department of Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands;

3. Department of Pathology and,

4. Department of Hematology, Radboud University Medical Centre, Nijmegen, The Netherlands; and

5. Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands

Abstract

Key Points The majority of suppressive Tregs in human secondary lymphoid organs are activated, produce cytokines, and proliferate. Human lymphoid organs may provide a platform for in vivo expansion of infused Tregs and subsequent tissue-directed homing.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/13/2213/1367937/2213.pdf

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