In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
Author:
Affiliation:
1. Department of Medicine, Division of Bone Marrow Transplantation, Stanford University, Stanford, CA;
2. Departments of Pediatrics, Radiology, and Microbiology & Immunology, Stanford University, Stanford, CA
Abstract
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/109/6/2649/1478051/zh800607002649.pdf
Reference41 articles.
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2. Takahashi T, Kuniyasu Y, Toda M, et al. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol1998; 10:1969–1980.
3. Thornton AM and Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med1998; 188:287–296.
4. Annacker O, Coombes JL, Malmstrom V, et al. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med2005; 202:1051–1061.
5. Gavin MA, Clarke SR, Negrou E, et al. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol2002; 3:33–41.
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