Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation-Reference-Cited by-同舟云学术

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

Published:2011-04-07 Issue:14 Volume:117 Page:3921-3928
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Di Ianni Mauro¹²,Falzetti Franca¹,Carotti Alessandra¹,Terenzi Adelmo¹,Castellino Flora³,Bonifacio Elisabetta¹,Del Papa Beatrice¹,Zei Tiziana¹,Ostini Roberta Iacucci¹,Cecchini Debora¹,Aloisi Teresa¹,Perruccio Katia¹,Ruggeri Loredana¹,Balucani Chiara¹,Pierini Antonio¹,Sportoletti Paolo¹,Aristei Cynthia¹,Falini Brunangelo¹,Reisner Yair⁴,Velardi Andrea¹,Aversa Franco¹,Martelli Massimo F.¹

Affiliation:

1. Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy;

2. Chair of Hematology, Department of Internal Medicine and Public Health, University of L'Aquila, Italy;

3. Translational Medicine, Novartis Vaccines and Diagnostic, Italy; and

4. Weizmann Institute of Science, Immunology Department, Rehovot, Israel

Abstract

Abstract Hastening posttransplantation immune reconstitution is a key challenge in human leukocyte antigen (HLA)–haploidentical hematopoietic stem-cell transplantation (HSCT). In experimental models of mismatched HSCT, T-regulatory cells (Tregs) when coinfused with conventional T cells (Tcons) favored posttransplantation immune reconstitution and prevented lethal graft-versus-host disease (GVHD). In the present study, we evaluated the impact of early infusion of Tregs, followed by Tcons, on GVHD prevention and immunologic reconstitution in 28 patients with high-risk hematologic malignancies who underwent HLA-haploidentical HSCT. We show for the first time in humans that adoptive transfer of Tregs prevented GVHD in the absence of any posttransplantation immunosuppression, promoted lymphoid reconstitution, improved immunity to opportunistic pathogens, and did not weaken the graft-versus-leukemia effect. This study provides evidence that Tregs are a conserved mechanism in humans.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/117/14/3921/1338009/zh801411003921.pdf

Reference24 articles.

1. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype.;Aversa;N Engl J Med,1998

2. Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse.;Aversa;J Clin Oncol,2005

3. Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice.;Bachar-Lustig;Nat Med,1995

4. Bone marrow transplantation across HLA barriers by increasing the number of transplanted cells.;Reisner;Immunol. Today,1995

5. Successful engraftment of T-cell-depleted haploidentical “three-loci” incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum.;Aversa;Blood,1994

Cited by 832 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. An immunocytokine consisting of a TNFR2 agonist and TNFR2 scFv enhances the expansion of regulatory T cells through TNFR2 clustering;Biochemical and Biophysical Research Communications;2024-02

2. Early T-cell reconstitution predicts risk of EBV reactivation after allogeneic hematopoietic stem cell transplantation;Clinical and Experimental Medicine;2024-01-27

3. Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity;Frontiers in Immunology;2024-01-12

4. How adoptive transfer of components of the donor immune system boosts GvL and prevents GvHD in HLA-haploidentical hematopoietic transplantation for acute leukemia;Bone Marrow Transplantation;2024-01-11

5. Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation;Cells;2024-01-11