Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis-Reference-Cited by-同舟云学术

Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis

Published:2019-08-21 Issue:14 Volume:134 Page:1119-1131
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Müller-Calleja Nadine¹²³,Hollerbach Anne¹²,Ritter Svenja¹²,Pedrosa Denise G.¹^ORCID,Strand Dennis⁴,Graf Claudine¹^ORCID,Reinhardt Christoph¹,Strand Susanne⁴,Poncelet Philippe⁵,Griffin John H.⁶,Lackner Karl J.²,Ruf Wolfram¹³^ORCID

Affiliation:

1. Center for Thrombosis and Hemostasis and

2. Institute for Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, Mainz, Germany;

3. Department of Immunology and Microbiology, Scripps Research, La Jolla, CA;

4. Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany;

5. BioCytex, Marseille, France; and

6. Department of Molecular Medicine, Scripps Research, La Jolla, CA

Abstract

Abstract Antiphospholipid antibody syndrome is caused by antiphospholipid antibodies (aPLs) that cause thrombosis and pregnancy loss. In a Plenary Paper, Müller-Calleja et al dissect the complex and multifaceted mechanism by which aPLs induce thrombosis through priming of monocytes and disruption of the balance of tissue factor activation and inhibition.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/14/1119/1223072/bloodbld2019001530.pdf

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