Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2

Author:

Rondeau Liam Emile1,Da Luz Bruna Barbosa1,Santiago Alba1,Bermudez-Brito Miriam1,Hann Amber1,De Palma Giada1,Jury Jennifer1,Wang Xuanyu1,Verdu Elena Francisca1,Galipeau Heather Jean1,Rolland Corinne2,Deraison Celine2,Ruf Wolfram34,Bercik Premysl1,Vergnolle Nathalie2,Caminero Alberto1ORCID

Affiliation:

1. Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada

2. IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France

3. Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany

4. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA

Funder

Canadian Institutes of Health Research

Paul Douglas Chair in Intestinal Research

Farncombe Family Digestive Health Research Institute

European Research Council

Richard Hunt AstraZeneca Chair in Gastroenterology

German Research Foundation

Publisher

Informa UK Limited

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