Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium-Reference-Cited by-同舟云学术

Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium

Published:2018-05-10 Issue:19 Volume:131 Page:2097-2110
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sacharidou Anastasia¹,Chambliss Ken L.¹,Ulrich Victoria¹,Salmon Jane E.²,Shen Yu-Min³,Herz Joachim⁴,Hui David Y.⁵,Terada Lance S.³,Shaul Philip W.¹,Mineo Chieko¹

Affiliation:

1. Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX;

2. Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY;

3. Department of Internal Medicine and

4. Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX; and

5. Department of Pathology, College of Medicine, University of Cincinnati, Cincinnati, OH

Abstract

Key PointsThe activation of PP2A in endothelium underlies thrombus formation induced by aPL in mice. Endothelial apoER2 serves as a scaffold for aPL-induced assembly of a Dab2 and SHC1- containing complex that assembles and activates PP2A.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/19/2097/1468356/blood814681.pdf

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