Correlating drug–target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase-Reference-Cited by-同舟云学术

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Correlating drug–target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase

Published:2016 Issue:9 Volume:7 Page:5945-5954
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Daryaee Fereidoon¹²³⁴⁵,Chang Andrew¹²³⁴⁵,Schiebel Johannes⁶⁷⁸⁹¹⁰,Lu Yang¹²³⁴⁵,Zhang Zhuo¹²³⁴⁵,Kapilashrami Kanishk¹²³⁴⁵,Walker Stephen G.¹¹¹³⁴⁵,Kisker Caroline⁶⁷⁸⁹¹⁰,Sotriffer Christoph A.¹²⁸¹³¹⁰,Fisher Stewart L.¹⁴¹⁵⁵,Tonge Peter J.¹²³⁴⁵

Affiliation:

1. Institute for Chemical Biology & Drug Discovery

2. Department of Chemistry

3. Stony Brook University

4. Stony Brook

5. USA

6. Rudolf Virchow Center for Experimental Biomedicine

7. Institute for Structural Biology

8. University of Würzburg

9. D-97080 Würzburg

10. Germany

11. Department of Oral Biology and Pathology

12. Institute of Pharmacy and Food Chemistry

13. D-97074 Würzburg

14. The Broad Institute

15. Cambridge

Abstract

A mechanistic PK/PD model that enables predictions ofin vivodrug activity and an assessment of target vulnerability.

Funder

National Institute of General Medical Sciences

National Institutes of Health

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC01000H

Reference36 articles.

1. Robust Salmonella metabolism limits possibilities for new antimicrobials

2. Functional cartography of complex metabolic networks

3. Challenges of antibacterial discovery revisited

4. Drugs for bad bugs: confronting the challenges of antibacterial discovery

5. Where will new antibiotics come from?

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1. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity;Journal of Medicinal Chemistry;2022-12-02

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3. Structure–Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors;Journal of Medicinal Chemistry;2022-08-29

4. System-wide profiling by proteome integral solubility alteration assay of drug residence times for target characterization;2022-06-27

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