Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity-Reference-Cited by-同舟云学术

Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity

Published:2022-12-02 Issue:24 Volume:65 Page:16510-16525
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cifone Matthew T.¹²,He YongLe¹²,Basu Rajeswari¹²,Wang Nan¹,Davoodi Shabnam¹²,Spagnuolo Lauren A.²,Si Yuanyuan²,Daryaee Taraneh²,Stivala Craig E.³^ORCID,Walker Stephen G.⁴,Tonge Peter J.¹²⁵^ORCID

Affiliation:

1. Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States

2. Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States

3. Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

4. Department of Oral Biology and Pathology, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States

5. Department of Radiology, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States

Funder

Genentech

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01380

Reference51 articles.

1. Drug–target residence time and its implications for lead optimization

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4. Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

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