Drugs for bad bugs: confronting the challenges of antibacterial discovery

Author:

Payne David J.,Gwynn Michael N.,Holmes David J.,Pompliano David L.

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Reference34 articles.

1. House of Lords Select Committee on Science and Technology Seventh Report. Resistance to Antibiotics and Other Antimicrobial Agents [online] , (Stationary Office, London, UK, 1998).

2. Shlaes, D. M. et al. Antibiotic discovery: state of the state. ASM News 70, 275–281 (2004).

3. Talbot, G. H. et al. Bad bugs need drugs: an update on the development pipeline from the antibacterial availability task force of the IDSA. Clin. Infect. Dis. 42, 657–668 (2006).

4. Wenzel, R. P. The antibiotic pipeline — challenges, costs, and values. N. Engl. J. Med. 351, 523–526 (2004).

5. Infectious Disease Society of America. Bad Bugs, No Drugs [online] , (2004). Seminal review by key opinion leaders on the shrinking investment by big pharma in antibacterial discovery, and the growing challenge of resistant pathogens.

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